Coronavirus vaccine Crack is an expert who anticipates an initial coronavirus infection will lend people some level of immunity for some amount of time. But they still don’t know what potpourri of antibodies, cells, and other markers in a person’s blood will signify that protection. And determining those “correlates of protection” is crucial both so individuals can know if they are again at risk, and so researchers can understand how well potential vaccines work, how long they last, and how to accelerate their development.
Now, vaccine research and determining the correlates of protection often take place at the same time, Mascola said. And with the coronavirus, vaccine developers “are taking advantage of the fact that we think we know what kind of antibody response to generate, and that’s what the designs are based on.”Something strange happened. On Monday, 18 May, Moderna, a biotech company based in the US, held a press conference in which it released positive preliminary data on its ongoing vaccine program for covid-19. Its stock price reached stratospheric heights.
The following day, perhaps suffering from the hangover of the initial euphoria, with the sobering realization that there is still a long way to go before any vaccine can be deemed successful, Moderna’s share price started to slide. We really need a vaccine. SARS-CoV-2, the pandemic coronavirus that causes covid-19 has infected over five million people globally. Ravaging much of Asia, Europe, and North America, it is now intensifying in South America and Africa. Because it is a new virus that spreads like wildfire, the only hope of ending the pandemic lies in a substantial portion of the global population developing some form of immunity.
Vaccine-watchers can take heart in knowing that there are now ten different vaccine candidates being tested on healthy volunteers. A further 114 are in earlier stages of development (including a handful by Indian companies). The top ten vaccines are in the stage where they’re being tested to see if they’re safe and if they actually can get an immune response. Then, more people will be vaccinated to see if the vaccines actually work. In the last hurdle, even more, people will be tested to get a clearer picture of whether the vaccine works in a diverse population. No vaccine has passed the second hurdle or gotten near the third hurdle yet, but the news so far is promising.
Four of the ten are inactivated vaccines, which contain actual virus particles that have been killed by chemicals. This is the basis for traditional vaccines that you and I have received for other diseases. Because they use actual viruses, the safety protocol is extensive. Of these four inactivated vaccines (all led by Chinese institutions), Sinovac Biotech Ltd has one which seems to be the furthest along the way.
The other six vaccines use experimental platforms that don’t actually need the virus. The downside is they’re very new and none of them have resulted in commercially-available vaccines yet. So, there’s more limited experience with working with these systems. Such immunity can come from fighting and clearing the virus, but at least half of the world’s population, and perhaps up to 70% would need to be infected to acquire such “herd immunity”. And because of the significant lethality of the disease especially among certain vulnerable populations, experts believe the loss of life that would occur in order to get to herd immunity quickly would make this option broadly undesirable.
There’s another way to beat the virus with a much softer landing: a vaccine. That’s why there has never been a push for a vaccine like this in human history, using so many different, unique platforms. And all vaccine-makers want something called “sterilizing immunity” in which the vaccine prevents infection altogether.
- Researchers at Israel’s Institute for Biological Research claimed they have completed the development of a vaccine for the SARS-CoV-2 virus
- The institute’s work is conducted according to an orderly work plan and it will take time
- The development of an effective coronavirus vaccine would help prevent the deadly disease, save lives
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